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Cystine uptake determined the sensitivity of acute myeloid leukemia cells to APR-246 Since cysteine is a biosynthetic precursor of GSH, we asked whether the ability of cells to provide cysteine for GSH synthesis underlies the sensitivity to APR-246

Considering its vital role in diagnosing and treating PFis, it is important to evaluate the mechanical properties of PF, which requires objective and reliable measurement techniques

The binding of the ethacrynic acid-glutathione conjugate shows that the contacts of the glutathione moiety with the protein are identical to those observed in crystal structures of the enzyme with other glutathione-based substrates and inhibitors

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, et al