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These include alterations in the monoaminergic system, changes in glutamatergic synaptic transmission, neuro-inflammation, alterations in the hypothalamic-pituitary-adrenocortical (HPA) axis, changes in brain-derived neurotrophic factor (BDNF), and hippocampal atrophy (Dolotov et al., 2022)

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Modifiers and Billing Guidelines Sometimes, a modifier is required to indicate that the injection is a separately billable service

Patients may notice: Asymmetry, swelling, or a mass or lump under the skin Pain in the torso or limb Weakness or numbness in an arm or leg Bowel or bladder incontinence (in the case of pelvic or spine tumors) With sarcoma surgery, the goal is to achieve margin negative resection, which means, in theory, there are no tumor cells found at the edge of the tissue that was removed around the tumor