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Smith, C

10.1186/1743-422X-7-146 Virol

The debate over oral glutathione's efficacy was largely settled by a landmark 6-month randomized, double-blind, placebo-controlled trial conducted at Penn State University

It means that excess amounts are typically excreted through urine rather than accumulating to toxic levels , making vitamin B12 supplementation generally safe even at higher doses, though adverse reactions such as hypersensitivity or acneiform rash can occur rarely