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Given both the extent of disability caused by age-related cataract and its costs, $5 to $6 billion per year 26 (Congressional Testimony of S.J

Table 1) (Choudhury and Ahmed 2006)

Therefore, it is important to investigate i) the impact of CKD on the heart in larger animals and ii) in a more clinically relevant scenario, where other (metabolic) comorbidities, such as DM, co-exist (i.e., the concept of a second hit)

The heavy subunit (molecular weight about 73 kDa) exhibits the catalytic activity of the native enzyme and is also responsible for the feedback inhibition by GSH