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Examples: manual muscle testing grades by major muscle groups transfer ability (sit-to-stand, bed-to-chair) gait observations and balance findings functional test results (timed sit-to-stand, walking tolerance, assistive device use) Step 3: Prove functional impact Link weakness to daily life: bathing, dressing, toileting meal prep, household mobility fall risk and safety concerns work limitations when relevant Step 4: Exclude focal and neurologic patterns Document why this is generalized rather than focal: no unilateral deficit pattern no dermatomal-only weakness pattern

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The goal for this cohort is to observe how MTX325 modulates PD biomarkers, although its unclear what specific biomarkers Mission is pursuing

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