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Post-Exertional Malaise (PEM): While not a cure for PEM, improving mitochondrial efficiency and reducing systemic oxidative stress can help raise a patient's energy envelope, making them slightly more resilient to the metabolic fallout of physical or cognitive exertion

Hypokalaemia (low blood potassium) in the first weeks of loading-dose treatment in patients who started severely deficient

Safety monitoring includes periodic checks of blood glucose, thyroid function, and adrenal function, as well as watching for any adverse effects

While semaglutides primary function is to regulate blood sugar levels, it also causes slowed gastric emptying