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Metallothioneins Overview Another important metal chelator SH compound and S-donor ligand, metallothioneins (MTs) are products of mRNA translation, characterized as low mass weight (414 kDa) Cys-rich metal-binding proteins, and are widely distributed in both prokaryotic and eukaryotic organisms (Cobbett and Goldsbrough, 1957) for the first time characterized MTs from horse kidneys as Cd-binding proteins