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However, clinical trials investigating these pathways, are subject to limitations including the heterogeneity in TBI severity/etiology, variations in experimental time points and the methods applied to measure metabolites

After a decade of human genetics studies focusing on disease risk, emerging results from genetic studies of disease progression suggest a multi-hit paradigm in which disease initiation and disease progression are not necessarily driven by the same mechanisms (Figure 3)

Gage Michael Campbell, freshman, Deans List, College of Arts and Sciences, biochemistry

The multidrug resistance protein 2 knockout mouse (Mdr2 / , also known as Abcb4 / ) lacks the protein MDR2, a canalicular phospholipid flippase, and demonstrates a complete absence of phosphatidylcholine in bile