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DSIP vs Antidepressants (Used Off-Label) Certain antidepressants, including trazodone and mirtazapine, are prescribed off-label for insomnia due to sedative properties

This strategy aimed to overcome first-pass hepatic metabolism and limited BBB penetration 126

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While TB-500 exhibits similar pro-angiogenic behavior, it lacks certain regionssuch as the Ac-SDKP motifbelieved to mediate cytoprotective effects during acute ischemic stress