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Supplementary Figure 8 (A, B) Cumulative data showing relative concentrations of decreased metabolites in the R vs A group

The anticancer activity of this compound is related to its pro-oxidant and antioxidant capacity due to its complex structure including double bond in the carbonic chain, the position and number of OH group and free phenolic hydroxyl in the catechol group, respectively (Kiokias et al., 2020)

Lineweaver-Burke plots of the data confirmed the uncompetitive inhibition mechanism with respect to ATP and CoA (Fig

Pharmacol Ther 47 : 137146 Pemble S, Shroeder KR, Spenser SR, Meyer DJ, Ketterer B, Taylor JB (1994) Human glutathione S-transferase (GSTT1) cDNA cloning and the characterization of a genetic polymorphism