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The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid

Ferroptosis pathways and therapeutic targets in spinal cord injury Targeting ACSL4/LPCAT3/15-LOX Proanthocyanidin significantly reduced ACSL4 and ALOX15 levels and increased GSH, GPX4, Nrf2, and HO-1 expression to inhibit ferroptosis and promote functional recovery from SCI (Zhou et al., 2020b)

346,347,348 The first is the exogenous route, in which the NADs are directly introduced into the obtained exosomes via electroporation, co-incubation, sonication, extrusion, and freeze-thaw cycling