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Subsequently, the SUVH-SDJ complex binds the CHH hypermethylated regions within the promoters of totipotency-regulating genes and recruits AHLs, increasing chromatin accessibility

This structured approach allows the body to respond effectively while maintaining safety and long-term effectiveness

SHP77 and DMS114 cells were co-transfected with the dCas9-Tet1 expression plasmid with or without the LentiGuide-Puro vector expressing sgRNA using the Effectene Transfection Reagent (#301425, QIAGEN, Hilden, Germany)