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In rare cases individual allergic reaction to copper or peptide

3.4 Other regulatory mechanisms of ferroptosis There are several classical signaling pathways, which either synergize with ferroptosis or act as upstream regulatory signals that influence cancer cell survival and proliferation, including PI3K/Akt, Wnt/-catenin, p53, ACSL4, Caspase-1-dependent pyroptosis, and AMP-activated protein kinase (AMPK)/ Beclin1 (BECN1) signal pathways

20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1

Additionally, the Acsl4 fl/fl Ksp Cre-ERT2 groups also exhibited lower tubular injury scores compared to the Acsl4 wt/wt Ksp Cre-ERT2 groups (Fig