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WP raised plasma amino acids and insulin more than LEAA, but neither affected leg blood flow

This metabolic program (Figure 1) includes increased nutrient uptake (mainly glucose often in combination with Gln) and increased flux of glucose through the glycolytic pathway and PPP, thereby generating essential building blocks for amino acid and nucleotide biosynthesis as well as NADPH necessary for driving reductive biosynthetic pathways (especially for nucleotides and FAs/lipids) and maintaining the redox homeostasis

Other metabolic pathways regulated by shear stress In addition to glycolysis, FA metabolism, and mitochondrial respiration, shear stress regulates other metabolic pathways in ECs with relevance to aging and vascular dysfunction

The rats were randomly put in the oxidative stress or placebo-treated control groups