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reported that 50% of ASMA-negative and 60% of ANA-negative patients converted to seropositive status within 39 (range 383) and 60 (range 3194) months, respectively [182]

The abundance of each protein was constrained from mass spectrometry data and a normalized time course of phosphorylation data was used as the input for pattern search algorithm (a global optimization technique) to fit the model to the totality of the gathered hepatocyte or HCC-specific data