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Oxidative stress can lead to a variety of health problems, including inflammation, aging, and chronic diseases such as cancer, diabetes, and cardiovascular disease

This diverse regulatory network allows CHAC1 to play a crucial role in maintaining cellular homeostasis and adapting to environmental stresses

Currently, the two conflicting methods of supplying D-lactate (DL) and depleting lactate manipulate macrophages toward the M1 phenotype for tumor immunotherapy

A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]