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These results undoubtedly indicate that stem cell therapy involves multiple mechanisms, and given that the pathogenesis of AILI is a dynamic process involving the transition from liver injury to liver regeneration, these molecular mechanisms may not be mutually exclusive but may act in a complementary or even sequential manner

Known off-target tendencies: Sequences resembling DNLYFQ , ENLYLQ , and EN-LFQ are cleaved at 110% the rate of the canonical site perfectly enough to produce a stoichiometric internal cleavage during a 16-hour overnight incubation The N-terminal Met of E

GK is supported by Ligue Nationale contre le Cancer (quipe labellise), AXA Chair for Longevity Research, Cancrople Ile-de-France, Institut National du Cancer (INCa), Fondation Bettencourt-Schueller, Fondation de France, FRM, Agence National de la Recherche, LabEx Immuno-Oncology and the European Commission (Apo-Sys, ArtForce, ChemoRes

Buratti, 2015) (Figure 2)