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In fact, the use of anesthesia in this study can be considered a limitation, since it is expected to alter neuronal activity and metabolism

We also highlight lipin-1 as a regulatory node at a key branchpoint in macrophage lipid metabolism, illustrating how lipid handling can influence inflammatory and pro-resolving macrophage responses in cardiometabolic disease

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The mitochondrial contact site and cristae organization system (MICOS), a mega complex that regulates cristae junction organization, has been shown to assemble near ERMES sites, and ERMES function is required for MICOS assembly [86]