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FIGURE 7 Endothelial cell aging is closely associated with the progression of various diseases, potentially exacerbating the senescence of surrounding cells and worsening pathological processes (Hwang et al., 2022)

Ketogenic diet The ketogenic diet is a high-fat, moderate protein, and extremely low-carbohydrate dietary pattern that has shown potential in recent years in the treatment of NDs by inducing the body to produce ketone bodies (such as beta-hydroxybutyric acid) as an alternative energy source

Within the ER, newly synthesised proteins are oxidised by PDI, which in turn are again re-oxidised by ER oxidoreductase 1 (ERO1) in a reaction that generates H 2 O 2 72 , reviewed by 76