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Vitamin C is a cofactor for a family of metalloenzymes with pleotropic biosynthetic and gene regulatory roles ( Gulo knockout mice with melanoma and breast tumors following supplementation with low dose oral vitamin C (0.15 g/L, Figure 1 ) (Polireddy et al., 2017)

Symptoms typically appear within minutes to an hour of administration and can range from mild skin reactions to more significant respiratory or cardiovascular effects

Microbiota-derived SCFA can induce the release of incretins, including peptide tyrosine-tyrosine (PYY) and GLP-1, which modulate hunger and glucose metabolism 59

The aim of this study was to prove our hypothesis that A-GSH functionalization increases brain endothelial internalization and BBB permeability of polymeric nanoparticles coupled with active agents, namely dopamine and ibuprofen, which have low brain penetration