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Trejo-Solis C et al (2023) Role of glycolytic and glutamine metabolism reprogramming on the proliferation, invasion, and apoptosis resistance through modulation of signaling pathways in glioblastoma

doi:10.1016/j.cbpa.2004.10.001 5

In that case, you may attribute it to common factors like stress and other lifestyle factors, not knowing that a melatonin deficiency could be the underlying cause