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Although there is no evidence that supplements are helpful in the treatment of psychosis in general, based on the published studies, we believe that if we can detect MTHFR polymorphism in individuals with various psychiatric diseases, we might be able to differentiate those MTHFR-related psychiatric patients from non MTHFR deficient patients and develop specific clinical treatment strategies, such as folate or methylfolate supplement to reverse the symptoms

however, they are not routinely discriminated by conventional HPLC detection (Lennard and Singleton, 1992

2024;28(7): e18221

Based on these observations, we next performed in silico molecular docking studies to predict how LCS3 physically interacts with GSR and TXNRD1