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Anti-Angiogenic Therapy The Food and Drug Administration (FDA) approved biological therapies in the form of tyrosine kinase inhibitors (TKIs), monoclonal antibodies and fusion peptides in non-small cell lung cancer, metastatic colorectal cancer, medullary thyroid cancer and renal cell cancer [70]

Where indicated, the protein synthesis inhibitor cycloheximide (CHX) (Sigma-Aldrich) and the proteasome inhibitor MG132 (Sigma-Aldrich) were added to HEK293 cells cultured with a final concentration of 25 g/ml and 10 M respectively in a time-course experiment

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