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Ultimately, parthanatos, associated with the overactivation of PARP1 due to DNA damage, is often evaded in breast and ovarian cancers by the overexpression of PARP1 or mutations in related pathways, which diminishes the effectiveness of PARP inhibitors in these instances (Pazzaglia and Pioli, 2019)

Predictive variables were assessed using Cox proportional hazards regression analysis, and the predictive value was evaluated using receiver operating characteristic curves