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The increment in vitamin C intake had a direct effect on its plasma and leukocyte concentration from the second and third months of study

These peptides exert their physiological actions by interacting with the various classes of OR present on both pre- and post-synaptic membranes of opioid and opioid target neurons (Besse et al., Receptor subtypes of mu, delta and kappa OR have been proposed from the pharmacological in vitro and in vivo studies, but at present there is no molecular evidence to account for a further subclassification

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Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression