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By exploring gut microbiome in subjects characterized by TMAO producer phenotypes, we identified 39 operational taxonomy units that were highly correlated to TMAO productivity, including Emergencia timonensis , which has been recently discovered to convert -butyrobetaine to TMA in vitro

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Further testing of individuals with ASD and CESLAC ruled-out secondary causes of fatty-acid oxidation deficiencies including multiple carboxylase deficiencies, zinc deficiency, elevated copper, generalized hyperlipidemia or hypercholesterolemia, and hypoglycemia

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