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2013;73(15):1681-9 Zhang XH, Wang L, Dong ZZ

Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)

In spinal cord tissues from patients with ALS, the expression of arachidonate 5-Lipoxygenase (ALOX5) and complement component 3 (C3) was markedly upregulated, accompanied by reduced GSH levels, elevated iron concentrations, and enhanced lipid peroxidation

These advances allow researchers not only to examine the entire TME but also to investigate specific cell subtypes within it