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10.1016/j.ymthe.2017.01.025 42 DengX.RuanH.ZhangX.XuX.ZhuY.PengH.et al (2020)

Notably, in this study, vitamin D appears to influence the development of pulmonary fibrosis through multiple biological pathways: vitamin D deficiency not only exacerbates the lung inflammation caused by bleomycin (similar to the effect observed in the case of vitamin C deficiency), but also increases the likelihood of the occurrence of EMT in the lungs, and these are all crucial steps in the pathogenesis of pulmonary fibrosis

Methods: Paired-biopsy samples from the GAN DIO-NASH-HCC model (52 weeks of diet) treated for 16 weeks with either vehicle, 30 mg/kg lanifibranor or 30 nmol/kg semaglutide (N=15-17 animals/group) were included

RNF4, an E3 Ubiquitin ligase, is pivotal for tumorigenesis in part by stabilizing oncoproteins and its role in DNA repair, thereby enhancing cancer cell survival and driving tumorigenesis