glutathione peroxidase 1 brain Glutathione Peroxidase-Catalase Cooperativity Is Required

The brain is particularly susceptible to oxidative stress given its limited antioxidant enzymatic capacity to counteract reactive oxygen species production (Ferreira et al., 2015)

10.1007/s00417-024-06388-y 33

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16 In addition, interactions between the intestine and liver are bidirectional, and hepatogenic inflammatory cytokines thus impair intestinal mucosal barrier function, disrupting tight junctions of the intestinal epithelium, and forming a malignant liver-gut cycle during NAFLD