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doi: 10.3389/fmicb.2018.01362 Received 16 February 2018 Accepted 05 June 2018 Published 02 July 2018 Volume 9 - 2018 Edited by Daniela De Biase, Sapienza Universit di Roma, Italy Reviewed by Amparo Querol, Consejo Superior de Investigaciones Cientficas (CSIC), Spain

In a subsequent study, the authors reported an increase in LPO and nitric oxide (NO) levels, together with significant alterations in GSH redox status in the blood of male Wistar albino rats (age 2 months) exposed to drinking-water containing aspartame at a dose of 40 mg/kg bw for 6 weeks (Proki et al., 2015)