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At mRNA levels, 4-HNE inhibited collagen II expression but induced MMP13 expression [78]

doi: 10.1016/j.freeradbiomed.2010.05.029

By binding to cardiolipin, Elamipretide stabilizes mitochondrial cristae, improves membrane integrity, and enhances oxidative phosphorylation (Minkler et al., 2015)