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Based on the pivotal molecules associated with energy metabolism in the myocardial tissue, a radar map was established that showed the changes in the energy metabolites in the cardiac under high-altitude hypoxia as well as the modulation of the metabolites by L-carnitine, trimetazidine, and L-carnitine combined with trimetazidine (Figure 7A)

Overcoming mutation-based resistance to antiandrogens with rational drug design

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