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Numerous studies have demonstrated that adherence to a MeDi, rich in diverse nutrients and phytochemicals, exerts anti-inflammatory, antioxidant, and anti-atherosclerotic effects, thereby lowering cardiovascular and cerebrovascular risk (Tuttolomondo et al., 2019)

Inflammation can also be induced by disrupting the proper communication between astrocytes and neurons

Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC et al (2020) Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

Resistance-associated mutations in the receptor tyrosine kinase (RTK) pathway or secondary KRAS mutations have been frequently observed in patients, particularly in CRC, where up to 73% of patients exhibit acquired genomic alterations upon disease progression (NCT03600883) [165]