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Cross-disease comparisons suggest that these modules recur across different organ niches, but their net effects are markedly context-dependent and are jointly regulated by disease stage (acute inflammation versus chronic tissue remodeling), tissue compartment (peripheral blood versus lesional tissue), as well as the spectrum of stimuli and therapeutic exposure, thereby leading to inconsistent directional outcomes of the same pathway across different models and time windows

Unlike GSTM1 and GSTT1 , however, where common polymorphisms result in complete gene deletions (Board, 1981), variant GSTP1 alleles differ from the consensus reference sequence by single amino-acid substitutions, resulting in less pronounced, less frequent and less well-characterised phenotypes (Peklak-Scott et al, 2008)

The zeta potential of the nanoparticles was measured to assess their colloidal stability

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S