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Researchers have developed conditional knockout mouse models to better understand the mechanisms by which SLC39A14 mediates Mn homeostasis

A lot of the work was preliminary but it was fascinating to see the potential overlaps emerge: the intramural studies early mitochondrial findings, Lipkins possible plasmalogen and epigenetic iron findings, the mitochondrial breakdowns that Prusty induced using ME/CFS plasma or HHV-6A reactivation, and Ron Daviss nanoneedle and plasma exchange results pointed to a general theme mitochondrial issues and problems with oxygen delivery/utilization which come to think of it, showed up on Day 1 with David Systroms, Maureen Hansons and Betsy Kellers presentations

& Thorpe, C

Verma et al., 2023a)