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To investigate their biogenesis, we perform cryo-electron microscopy and liposome tubulation assays, showing that Arabidopsis SNX1 generates shorter membrane tubules than its mammalian counterpart, consistent with reduced membrane affinity linked to differences in the amphipathic helix

Compared with -glucuronidase-based systems, -galactosidase-cleavable linkers are generally considered to favor intracellular activation, offering a release profile that may enable more controlled drug liberation with reduced reliance on extracellular bystander effects

In South Korea it is 12 per 100,000 inhabitants [12], while it is higher in China with an estimated incidence of 24 per 100,000 [13]

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