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Since gout is directly related to uric acid levels in the blood, these risk factors are primarily associated with the production and excretion of uric acid: Diet: Foods such as red meat, certain seafoods (i.e., shrimp and oily fish), alcoholic beverages (especially beer), sugar, and fructose (often found in soft drinks) can all increase uric acid levels

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Furthermore, by interfering with folate metabolism and the one-carbon cycle, B 12 deficiency raises homocysteine levels and risks of related health problems

For example, exposure to pyocyanin mediated ROS to human airway epithelial cell activate NF-B and other inflammatory signaling pathways, leading to the production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-) and interleukins (IL-1, IL-6, IL-8) (93)