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Without a clear calculation method, it is easy to end up with concentrations that are either too strong or too weak

Hwang J

Glossary EEDs Environmental Endocrine Disruptors AR Androgen Receptor ER Estrogen Receptor Er/ER Estrogen Receptor Alpha/Beta SRC-1 Steroid Receptor Coactivator-1 GPCR G-Protein-Coupled Receptor PKA Protein Kinase A cAMP Cyclic Adenosine Monophosphate Ca Calcium Ion HSD17B 17-Hydroxysteroid Dehydrogenase CYP19 Cytochrome P450 Aromatase CYP1A1/CYP3A4 Cytochrome P450 Family 1A1/3A4 GSH Glutathione GST Glutathione-S-Transferase ROS Reactive Oxygen Species Drp1 Dynamin-Related Protein 1 Mfn2 Mitofusin 2 PINK1 PTEN-Induced Kinase 1 ARE Androgen Response Element miRNA MicroRNA lncRNA Long Non-Coding RNA NEAT1 Nuclear Paraspeckle Assembly Transcript 1 DMR Differentially Methylated Region DNMT1/3A/3B DNA Methyltransferase 1/3A/3B TET1/2 Ten-Eleven Translocation Methylcytosine Dioxygenase 1/2 EZH2 Enhancer of Zeste Homolog 2 KDM6B Lysine Demethylase 6B piRNA Piwi-Interacting RNA LINE-1 Long Interspersed Nuclear Element-1 NMDR Non-Monotonic Dose-Response TEF Toxic Equivalence Factor TDI Tolerable Daily Intake ED50 Median Effective Dose BCF Bioconcentration Factor PCB Polychlorinated Biphenyl PAHs Polycyclic Aromatic Hydrocarbons PBDEs Polybrominated Diphenyl Ethers BPA Bisphenol A DEHP Di(2-ethylhexyl) Phthalate HBCD Hexabromocyclododecane PCDD/Fs Polychlorinated Dibenzo-p-dioxins and Furans AGD Anogenital Distance iPSCs Induced Pluripotent Stem Cells scRNA-seq Single-Cell RNA Sequencing ATAC-seq Assay for Transposase-Accessible Chromatin using Sequencing CRISPR Clustered Regularly Interspaced Short Palindromic Repeats ROI Return on Investment FSH Follicle-Stimulating Hormone LH Luteinizing Hormone MDA Malondialdehyde SOD Superoxide Dismutase NOAEL No Observed Adverse Effect Level WHO World Health Organization EFSA European Food Safety Authority EPA Environmental Protection Agency

In a phase 2 trial, people with T2D and overweight/obesity achieved greater mean WL with cagrisema 2.4 mg compared to cagrilintide 2.4 mg or semaglutide 2.4 mg alone after 32 weeks of treatment (15.6% WL vs