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PMID: 1318377 Ferreira S, Crumb WJ Jr, Carlton CG, Clarkson CW (2001): Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel

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Notably, the liver, a primary organ for threonines initial catabolism, demonstrated a notable increase in SDS activity, facilitating threonines conversion into propionyl-CoA across all detected organs during fasting, likely due to the inter-organ cross-talk mediated by downstream metabolites, although muscle SDS activity remained unchanged