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In vitro models to study confinement-induced responses include micropatterned lines [151], 2D micropatterned substrates [85], uni-axial compression [152], polydimethylsiloxane [153,154,155,156]- or polyacrylamide [90]-based microchannel devices, microniches [157, 158], and natural hydrogels [148, 159]

Patients should inform their healthcare provider about any history of allergies or hypersensitivities to medications

Early prevention often reduces the risk of severe symptoms linked to the 4 stages of B12 deficiency

Etiology primarily includes autoimmunity but it can also occur secondary to viral infections and even vaccination