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The cag PAI , a 40 kilobase segment of DNA is a group of about 30 genes, many of which encode components of type IV secretion system (T4SS) that acts as a "molecular syringe" through which cytotoxin-associated antigen (CagA), a protein encoded on the cag PAI, is translocated or "injected" into the epithelial cytosol causing powerful changes which is believed to benefit the bacterium

Thus, chemosensitization could make the use of toxic antifungal drugs or fungicides more attractive as a chemotherapeutic strategy, and to overcome development of pathogen resistance to conventional antimicrobial agents

doi: 10.1667/rr1389.1 72 MannaS

7.4 Current knowledge gaps Several critical knowledge gaps limit the evidence-based application of gerontological peptides