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Nevertheless, across studies, lipid profile measures (total cholesterol, HDL-C, triglycerides), glucose, and insulin typically exhibit negligible or inconsistent variations, especially in short-duration interventions [102]

Notably, ANGII-induced left ventricular hypertrophy and remodeling occurred both in the presence (Ichihara et al., 2001) or absence (Matsumoto et al., 2013) of hypertension, suggesting that hypertension may not be the primary mechanism by which ANGII induces cardiac remodeling

Int J Environ Res Public Health 17(2):128 Bian H, Wang G, Huang J, Liang L, Zheng Y, Wei Y, Wang H, Xiao L, Wang H (2020) Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

When metallodrugs bind to channel proteins, the ion channel activities can be modulated, such as Zinc, which can modulate NMDA receptors (Lee et al., 2023)