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Another anti-CD38 mAb, Isatuximab, has also shown significant antitumor activity by a more potent action of direct cell killing different from crosslinking, mediated by activation of caspases-7 and 8, lysosome permeabilization, upregulation of reactive oxygen species (ROS), as well as ADCC, CDC, and ADCP mentioned above [80, 81]

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Thurmond, Beckman Research Institute, City of Hope, United States Reviewed by Lei Jiang, City of Hope National Medical Center, United States

The body is constantly moving fluids by various mechanisms, but the compartmental volumes stay relatively constant