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Indeed, when HNE or alkyne-HNE was co-incubated with N-acetylcysteine (NAC) that contains a reactive cysteine, which can inactivate cysteine-reactive metabolites, the ability of HNE to protect cells from nigericin-mediated cell death, IL-1 release and MitoSOX nuclear accumulation was eliminated (Fig

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34.Liso, R., Innocenti, A