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During this process, ROS are generated as by-products for the partial four-electron reduction of O 2 to produce water molecule, which is the last electron acceptor in the ATP generation process (Ambrosio et al., 1993)

JAMA Network Open 5(6), 2022

The release of nitric oxide activates the guanylate cyclase-1-cGMP pathway, which promotes relaxation of the TM and facilitates increased AH outflow (43)

Even moderate alcohol intake increases oxidative damage and liver injury in HBV-infected patients ( 2 Clinical evidence linking alcohol consumption to HBV-associated end-stage liver disease and HCC Clinical studies indicate a strong association between HBV, alcohol, and HCC