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For example, carriers of the HLA-DRB1 * 01:03 allele (approximately 3% of patients) have a greater than 40% risk of requiring major intestinal surgery within 3 years of diagnosis (Vestergaard et al., 2024)

IGF-1 is broadly implicated in cell proliferation, extracellular matrix organization, angiogenic signaling, and tissue regeneration, which is why GH-axis stimulation is frequently studied in relation to repair processes