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The meninges host diverse innate and adaptive immune cells, which are distributed in varying amounts across the distinct meningeal layers to enable tissue-specific functions

One case study involving a child with one pathogenic ACADVL mutation showed that it combined with common ACADVL variants to cause significantly reduced enzyme function.[ref] Another study in infants with a positive newborn screening for decreased VLCAD showed that they had a single copy of a mutation in the ACADVL gene