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10.18632/oncotarget.8562 129 HeX

FIGURE 5 2.7 Pyroptosis Pyroptosisa lytic inflammatory cell death executed by gasdermin family protein-mediated nanoscale pore formationreleases pro-inflammatory cytokines (IL-1/IL-18) to amplify immune responses, with its molecular basis established through the identification of GSDMD as the executioner via caspase-1-mediated proteolysis (Rao et al., 2022) (Vasudevan et al., 2023) ( 2+ -dependent repair (Wei et al., 2022), whereas acute induction triggers immunogenic cell death through DAMPs and cytokines (IL-1/IL-18) that enhance dendritic/NK cell activation and cytotoxic T cell priming, reshaping immunosuppressive microenvironments (Wang et al., 2024) (Figure 6)

Dual sources of melatonin and evidence for different primary functions

With proper medical consultation, low-dose sessions may be suitable, as glutathione supports liver detoxification