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In patients with WD with reproductive dysfunction, engineered extracellular vesicles delivering a copper-chelating ligand significantly reduced non-ceruloplasmin-bound copper (42.7%) and urinary copper (47.7%), normalized gonadotropin levels in 87.5% of patients and exhibited a favorable safety profile (6.25% mild gastrointestinal events) (231)

When cells experience oxidative stress, Nrf2 dissociates from its repressor, Keap1, moves into the nucleus, and triggers the production of key antioxidant enzymes, such as catalase, superoxide dismutase (SOD), and glutathione peroxidase [35]

The ability of silver to target multiple pathways also lowers the propensity of resistance acquisition by microbes, which is commonly observed among antibiotics with single targets (25)

At predetermined time points (0.0833, 0.25, 0.5, 1, 2, 4, 8, 12, 24, and 48 h), about 0.2 mL of blood was collected from the tail vein in a heparinized tube after injection