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Zhu B, Li L, Wei R, Liang P, Gao X

DON treatment decreases lactate and histone lysine lactylation (Kla) Glycolysis serves as the primary energy-supplying pathway in granulosa cells 37

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Finally, iNOS itself is inhibited by S-nitrosylation (131, 132), suggesting that NOS uncoupling may be further perpetuated by an increase in iNOS expression under conditions that support superoxide production and BH4 depletion supporting the idea that NOS uncoupling may function as a molecular switch